Endocrine Abstracts

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

Objective: Thyroid hormones are required not only for central nervous system development in the early stages of life but also play a key role in the maintenance of adult brain function. It is known that in adults, thyroid diseases can lead to various clinical manifestations i.e affective disorders, depression, memory impairment. The effects of hypothyroidism on brain functions seem particularly pronounced in depression, but until now, the mechanism underlying this relationship...

We study the impact of the dehydroepiandrosterone (DHEA) by the women with diminished ovarian reserve and very low DHEA-S in the blood.Patients: We present a description of 7 patients with diminished ovarian reserve (DOR). Patients reported because of problems with getting pregnant. Infertility lasted for several years. The patients disagreed on IVF for ethical and religious reasons. All of the presented patients were diagnosed with diminished ovarian re...

A 59-year-old female presented with apathy and 6 kg weight gain. Investigations revealed primary hypothyroidism (TSH >100 μIU/ml). Thyroxine (L-T4) was started and titrated up to 75 μg, o.d., with clinical improvement. Other investigations revealed high titres of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After three months, there was a fall in TSH to 12.74 μIU/ml, however, with unexpectedly high free T4 (...

Metoclopramide (MCP) is a selective blocker of dopamine D2 receptor, responsible for the dopamine inhibition of prolactin (PRL) secretion from the pituitary. In normal conditions, administration of the proper dose of MCP leads to increase of PRL concentration in the blood serum. This response was applied in the diagnostic test (MCP test), useful to differentiate between hyperprolactinaemia linked with organic causes (prolactinoma and other lesions of hypothalamo-pituitary regi...

Immunohistochemical detection of angiotensin receptors AT1 and AT2 in adrenal tumorsAngiotensin II is well known to affect the adrenal cell growth and function. Angiotensin receptors AT1 and AT2 were found to be present in the normal adrenal gland. However, the data on the expression of angiotensin receptors in the adrenal tumors is very scarce.To overcome this gap, the paraffin sections of the adrenal cortical tumors and of pheoch...

We report pregnancies obtained after stimulation by gonadotropins in 3 patients with IHH caused by homozygous or compound heterozygous mutations of GnRH receptor: (R139H/R262Q, R139C/ R139C, R139H/ Phe 308 del.);Gonadotropin response to GnRH was observed in the first patient. All the patients were stimulated with gonadotrophins according to the protocole step up with the initial dose of 150IU FSH and 75 IU LH a day. The luteal phase was suported by hCG a...

Background: Polycystic ovary syndrome (PCOS) is a heterogenous endocrinopathy commonly diagnosed in reproductive age women, predisposing to the development of metabolic disturbances. However, the mechanisms underlying the connection between PCOS and metabolic disorders are still not well understood. The aim of the study was to investigate amino acid (AA) profile in women with PCOS and to assess its relation with metabolic disturbances.Methods: 326 women:...

Introduction: Recently, the immune hypothesis of depression has gained a new dimension because of inflammasomes. NLRP3 inflammasome is a protein complex and its activation leads to stimulation of the enzyme caspase 1 responsible for generation of active form of pro-inflammatory cytokines: IL-1 β and IL-18. Recently postulated ‘inflammasome theory of depression’ assumes that depression is based on a disturbance of the mechanisms regulating NLRP3 complexes and unc...

Background: The association between fat mass and obesity-associated gene (FTO) polymorphism rs 9939609 and obesity was found in some European countries. However, the data concerning Polish population is insufficient. The relationship between FTO and metabolic disorders remains unclear.Methods: The study group consisted of 686 women and 418 men from Lower Silesia in Poland, aged 30–80 years (mean age 54.2±9.26 years). The examination included an...